9,707,403 Full-Text Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics
9,636,507 Full-Text Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics
9,492,478 Full-Text Encoded bioelectronic method and system and calcium treatment for slaying cancer by rapid triggering of cellular apoptosis and karyorrhexis
9,440,083 Full-Text Rapid destruction of malignant tumors by excitotoxicity and osmotic-shock medical tactics
9,295,835 Full-Text Encoded bioelectronic method and system and calcium treatment for slaying cancer by rapid triggering of cellular apoptosis and karyorrhexis
9,032,964 Full-Text Method and system for processing cancer cell electrical signals for medical therapy
8,831,738 Full-Text System and method to elicit apoptosis in malignant tumor cells for medical treatment
8,656,930 Full-Text Method and system for processing cancer cell electrical signals for medical therapy
8,315,712 Full-Text Hybrid scientific computer system for processing cancer cell signals as medical therapy

Tumor therapy
Patent number: 11185691
Abstract: Described are a system and method that “reads” cancer tumors real time and custom delivers individualized bioelectric therapy to the patient. For example, the system reads a cancer tumor, and based upon this read, delivers to the subject “a confounding signal” to jam communication within that tumor. A cancer tumor may change its communication patterns and the therapy is designed to change with these patterns, attempting to always jam the relevant communication signaling pathway. The described system includes parameters not tied to communication jamming, which should also be customized to induce apoptosis to the cancer tumor. Such parameters include signals for starving a cancer tumor of blood supply and signals for changing the cancer tumor’s surface proteins and/or charge so that the immune system attacks the cancer tumor.
Type: Grant
Filed: September 20, 2018
Date of Patent: November 30, 2021
Assignee: LEONHARDT VENTURES LLC
Inventors: Howard J. Leonhardt, Jorge Genovese
System and method for treating inflammation
Patent number: 11110274
Abstract: Described is a low voltage, pulsed electrical stimulation device for reducing inflammation in a subject, which can be useful in the treatment of concussions, traumatic brain injury, cancer, and so forth.
Type: Grant
Filed: September 20, 2018
Date of Patent: September 7, 2021
Assignee: LEONHARDT VENTURES LLC
Inventor: Howard J. Leonhardt
BIOELECTRIC OPG TREATMENT OF CANCER
Publication number: 20200330759
Abstract: Described is a method of treating a subject diagnosed with cancer, breast cancer, bone cancer, lung cancer, osteoporosis, multiple myeloma, and a combination of any thereof by applying a bioelectric signal or signals that upregulate the expression of Osteoprotegerin (“OPG”) and thus beneficially effect the subject’s OPG/RANKL/RANK pathway.
Type: Application
Filed: June 26, 2020
Publication date: October 22, 2020
Inventors: Howard J. Leonhardt, Jorge Genovese.

KLOTHO MODULATION
Publication number: 20200289826
Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of klotho, a useful protein, by tissues. Also described are methods of enhancing expression of klotho in cells.
Type: Application
Filed: March 13, 2019
Publication date: September 17, 2020
Inventor: Howard J. Leonhardt

Stimulator, pump and composition
Patent number: 10646644
Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.
Type: Grant
Filed: March 15, 2017
Date of Patent: May 12, 2020
Assignee: CalXStars Business Accelerator, Inc.
Inventors: Howard J. Leonhardt, Jorge Genovese